Generic Name: TIZANIDINE - ORAL Pronounced: (tize-AN-ih-deen) Tizanidine Oral Uses: This medication is used to treat muscle tightness and cramping (spasm) caused by conditions such as multiple sclerosis or spinal injury. Decreasing spasms can reduce pain and improve your ability to move around. Tizanidine is a short-acting muscle relaxant that works by blocking certain nerve signals from the spine to the brain (alpha adrenergic agonist). Tizanidine may also be used for purposes other than those listed in this medication guide. Please consult your physician before taking any medication.