Why is Premarin prescribed? Premarin is an estrogen replacement drug. The tablets are used to reduce moderate to severe symptoms of menopause including feelings of warmth in the face, neck, and chest, and the sudden intense episodes of heat and sweating known as "hot flashes." Cenestin tablets, containing a synthetic form of conjugated estrogens, may also be prescribed for these symptoms. In addition to the symptoms of menopause, Premarin tablets are prescribed for teenagers who fail to mature at the usual rate, and to relieve the symptoms of certain types of cancer,including some forms of breast and prostate cancer. Premarin may also be used for purposes other than those listed in this medication guide. Please consult your physician before taking any medication.