DEXAMETHASONE INDOMETHACIN INDICATIONS For treatment of acute manifestations and exacerbations of severe inflammatory diseases like rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, juvenile rheumatoid arthritis, moderate to severe, acute gouty arthritis, bursitis, tendonitis, capsulitis and synovitis. Indomethacin is a nonsteroidal anti-inflammatory indole derivative with analgesic properties superior to aspirin. Its mechanism of action involves the inhibition of cyclooxygenases 1 and 2, which produces prostaglandins that are fundamental to the inflammatory process and in reducing the migration of polymorphonuclear leukocytes