Generic Name: Fluocinolone/Hydroquinone/Tretinoin (floo-oh-SIN-oh-lone/hye-droe-KWIN-one/TREH-tih-noyn) Brand Name: Tri-Luma Tri-Luma is used for: Short-term treatment of moderate to severe melasma (darkening) of the face. It is used in combination with sun avoidance measures, including sunscreen use. It may also be used for other conditions as determined by your doctor. Please consult your physician before using any medication.