Please consult your physician before taking any medication. Generic Name: Acyclovir Cream (ay-SYE-kloe-veer) Brand Name: Zovirax Acyclovir Cream is used for: Treating cold sores on the face or lips that are caused by the herpes virus. It may also be used for other conditions as determined by your doctor. Acyclovir Cream is an antiviral. It works by stopping viral replication. However, Acyclovir Cream does not eliminate the herpes virus, it is not a cure, and it does not prevent transmission to others.