Analgesics WHO classification

Analgesics for pain may have anti-inflammatory and antipyretic effect. The world health organization classifies all painkillers to anti-inflammatory and opioid analgesics.

Opioid analgesics, in turn, are divided further into 2 subtypes:

• Agonists of opioid receptors – morphine and oxycodone

• Agonist-antagonists and partial agonists of opioid receptors

What does the opioid analgesic mean

Opioid analgesics are used during short-term intense pain. Sold only by prescription. Long-term intake of narcotic analgesics cause addiction and withdrawal symptoms.

Opioid analgesics affect the brain and spinal cord. It can be prescribed by a doctor when you can’t receive NSAIDs due to allergies, impaired renal function and liver, diseases of the gastrointestinal tract. Not assigned to the patient if his story was the abuse of drugs, alcohol. To determine suitability for long-term use of opioid analgesics, the doctor uses a tool such as DIRE (Diagnosis, Intractability, Risk and Efficacy). A high score means that the patient can be treated with opioids.

Opioid analgesic pain medicine in the abrupt cancellation may cause symptoms such as nausea, nervousness, frequent mood changes, insomnia, headache, sweating.

Anti-inflammatory analgesics

Anti-inflammatory analgesics are divided into the following varieties:

• Salicylic acid derivatives

• Derivatives phenacetin

• Pyrazolone derivatives

Salicylic acid derivatives (e.g. aspirin) used for mild pain. The drug also has anti-inflammatory effect. Derivatives phenacetin aspirinate can include analgesics, nonsteroidal anti-inflammatory drugs. To such belongs drugs ibuprofen, naproxen, fenoprofen. Pyrazolone derivatives in many countries are not applied due to risk of agranulocytosis.

When choosing analgesic medicine should consider the following factors: the origin of pain, interactions with other drugs you take, the intensity of the pain, allergic reactions, chronic disease. The right decision is always to consult your doctor.

What is topical analgesic

Topical analgesic pain medicine acts directly on the location of the pain, for example when you stretch the muscles from the pain or trauma. The advantage of local painkillers that the number and severity of the side effects are minimal. These medicines come in the form of a gel, cream or spray.

Topical analgesic can include components such as:

• Menthol, oil of evergreens and camphor, which have anti-inflammatory action. These components can create both a cooling and warming effect.

• Salicylates will help with pain in the joints, especially those that are located close to the skin: elbow, knee, knuckles.

• Capsaicin is the main component of chili peppers. It has a powerful warming effect. Burning and tingling you need to endure, over time this feeling fades and finally disappears. Creams and gels based on capsaicin good help for pain in the joints and nerves diabetic.

What does do analgesic

Analgesics for pain unlike anesthetics do not block the conduction of nerve impulses, does not affect the mind or alter sensory perception.

WHO analgesic ladder

The analgesic ladder was developed by the World Health Organization with the aim to offer appropriate and effective treatment to patients with cancer and other diseases with intense pain. According to the table therapy using analgesics was as follows:

1. The appointment of opioid analgesics.

2. If therapy is ineffective, administration of a weak opioid in addition to the non-opioid analgesic.

3. In case of treatment failure, the appointment of a strong opioid and non-opioid analgesic.

The analgesic ladder has been adapted and today there are 4 stages of pain intensity and pain therapy.

1. Non-opioid analgesic, non-steroidal anti-inflammatory drug.

2. Weak opioid

3. Strong opioids (methadone) by oral route of administration, transdermal patches

4. Receptor blockers, microinfusion pump, epidural anesthesia, brain stimulants, neurolysis.

 What does analgesics treat

Analgesic medicine is used in the following cases:

• Field of injury;
• For headache or toothache, after tooth extraction;
• Pain during menstruation;
• Rheumatoid arthritis;
• Fever;
• Migraine;
• Sprain, damage to joints;
• Postoperative pain;
• Prevention of myocardial infarction;
• Heart pain caused by angina pectoris;
• Prevention of a heart attack;
• Prevention of peripheral arterial thromboembolism

 Which analgesics have antipyretic properties

During fever, analgesic medicine, which has an antipyretic effect, can be used.  We list the analgesics that have these properties:

• NSAIDs: ibuprofen, nimisulide, ketoprofen, naproxen

• Salicylates: aspirin

• Paracetamol

• Nabumeton

• Phenazone (antipyrine)

Why do analgesics contain caffeine

It is known that caffeine can be effective in treating headaches, but there is also such a phenomenon as ricocheting headaches.  That is why analgesics for pain with caffeine should be prescribed by your doctor.

Caffeine can increase the effectiveness of analgesics by 40%.  Another property of caffeine-containing painkillers combined is the reduction of side effects and addiction syndrome compared to taking high-dose analgesics.

What analgesics contain caffeine:

• Vivarin: 200 mg

• NoDoz Maximum Strength: 200 mg

• Aspirin-Free Excedrin Caplets: 65 mg

• Excedrin Extra Strength Caplets and Tablets: 65 mg.

• Excedrin Migraine: 65 mg.

• Goody’s Cool Orange Powder: 65 mg.

• Pain Reliever Plus Tablets: 65 mg.

• Midol Menstrual Maximum Strength Caplets: 60 mg.

• Vanquish Caplets: 33 mg.

• Goody’s Extra Strength Headache Powder: 32.50 mg.

• Anacin Maximum Strength: 32 mg.

• Anacin Tablets and Caplets: 32 mg.

• Goody’s Extra Strength Tablets: 16.25 mg.

All drugs can be bought without a prescription.  In addition to taking analgesic pain medicine with caffeine, you can use drinks that contain caffeine, for example: hot chocolate, green tea, chocolate and coffee liqueurs.

Analgesic medicine is available in the Analgesic section at affordable prices.  Medicines shipped from Mexico are a convenient and cost-effective way to get medicine without sacrificing your budget.  If you have prescription drugs, please contact our specialists.  We will check your recipe and ship the order as soon as possible.

What is migraine

Migraine headache, which is localized on one side of the head. May be medium to high intensity. Often a headache is accompanied by pulsation, nausea, vomiting, photophobia, hypersensitivity to smells and sounds. Severe headache for 3 days or more must be diagnosed in order to exclude serious diseases of the brain.

There are migraines without aura and with aura, which is manifested by short-term visual impairment. Aura – a premonition of an oncoming headache in the form of various symptoms. It can be observed both before and during the onset of migraine.

Symptoms of migraine aura:

• Bright spots or flashes in front of the eyes;

• Tingling in arms or legs;

• Slow speech;

• Involuntary movements, jerking of hands or feet;

• Short-term auditory hallucinations;

• Numbness on one side of the body or face.

In most cases, women with migraine suffer from the disease 2-3 times more often than men. Also, migraine can occur against a background of changes in the hormonal background, pregnancy.

Where is the migraine localized?

Migraine occurs in one hemisphere of the head or in part. When asked how to describe the nature of the headache, patients often answer: “It seems that the head is split into two parts.”

What symptoms can tell about a previous migraine

People who experience regular migraines may experience previous symptoms. For example, the following symptoms may occur within a few days:

• Frequent yawning;

• Constipation;

• Increased hunger;

• Frequent change of mood;

• Thirst;

• Frequent urination.

Why does migraine occur?

Doctors explain the appearance of migraines – a genetic predisposition. Especially often this disease is transmitted through the female line. At the genetic level, features of the functioning of the nervous system are transmitted.

Migraine occurs due to activation of the trigeminal nucleus, which leads to spasm. Then there is an expansion of the arteries of the brain, and after that – perivascular edema. All these processes cause a strong throbbing headache.

What causes migraine

Regular migraines can occur due to many factors. Medical experts divide these factors into 4 main groups:

1. Physiological

2. Psychological

3. Food

4. External

The physiological causes of migraines include mental overstrain, lack of sleep or frequent awakenings at night, changes in hormonal levels. Psychological stresses include stress and overwork at work (physical, emotional). Nutritional factors include eating foods that contain toxic substances. Thus, the body responds to intoxication. Doctors also talk about some foods that contain Tyramine:

• Legumes

• Pickles

• Spices

• Nuts

• Avocados and plums

• Bananas and citrus fruits

• Flour

• Smoked meat

• Milk products

• Alcoholic drinks

• Chocolate and coffee

External factors that trigger migraines: atmospheric phenomena, frequent changes in weather and ambient temperature, pungent odors, constant or periodic stay in a stuffy room.

In women, migraine can occur during pregnancy, lactation, menopause, and taking contraceptives.

Another hypothesis of the occurrence of migraine is the narrowing of the vascular lumen or, conversely, vasodilation.

When a doctor can diagnose a migraine

It is difficult to diagnose migraines directly through examination. The doctor may diagnose Migraine when other possible causes of severe headache are ruled out. To do this, you need to do an MRI of the brain.

How do migraines occur?

As mentioned above, a severe headache within 3 days can follow an aura that lasts from 10 to 30 minutes and a third of patients with migraines occur.

The next stage is directly a migraine attack or severe headache. Duration from several hours to several days. Usually the pain is localized on one side of the hemisphere, but it can be on both sides. Pain with high intensity begins to pulsate during movement or physical activity. During seizures, a person is unable to perform work or even household tasks, cannot drive a car. The patient has a desire to accept a prone position, to limit himself from sounds, smells and light.

After the attack phase, the resolution phase follows. It is characterized by a feeling of emptiness. The head becomes “heavy.” The patient feels overwhelmed, tired, irritated. This condition can last a day.

How to relieve migraines

Migraine pain treatment consists of taking analgesics and combined caffeinated drugs. The dosage and type of medication should be selected by the doctor. Antiemetics will help relieve symptoms of nausea and vomiting.

In the event that analgesics and antiemetics do not have an effect, with a migraine attack, the doctor may prescribe medications for migraine. Medications can be taken according to the following schemes:

1. As soon as you feel the imminent symptoms of migraine or signs preceding it, you should take a medication. In this case, at least one dose should always be at hand.

Caution! Too frequent use of anti-migraine drugs can lead to withdrawal symptoms, so do not use them with ordinary headaches. Doctors do not recommend the use of drugs against migraine more often 2-3 times a week.

2. Preventive treatment of migraine involves the regular use of drugs to prevent migraines. May be prescribed if another type of treatment does not help. The type of drug and dosage must be prescribed by a doctor, so as not to cause addiction and withdrawal.

Migraine Treatment During Pregnancy

A particularly difficult problem is the appearance of migraine during pregnancy. Due to a change in the hormonal background, a woman can become a hostage to a constant headache. Headache treatment for migraines at home is complicated by the fact that you can not take most of the analgesics and drugs for migraines, as they can affect the fetus.

Headache treatment for migraine at home during pregnancy is possible only after the exclusion of secondary signs of migraine:

• High or low blood pressure

• Venous discirculation

• ICP

Treatment of pain with migraine in the expectant mother should be only those drugs that are allowed during pregnancy. Therapy may include magnesium drugs, NSAIDs (non-steroidal anti-inflammatory drugs), tricyclic antidepressants, beta blockers.

Migraine treatment

It is impossible to cure a migraine 100%, since it is a disease transmitted by inheritance. However, there are a number of preventative measures that will help to avoid factors leading to migraine.

1. Keep a migraine diary

In your personal diary, observe how often pain occurs, what intensity and duration they are, what you did the day before. After analyzing this data, you can find out what exactly leads to pain in your particular case.

2. Exclude foods that can lead to migraines (discussed above)

3. Sports, regular physical activity (not necessarily heavy)

4. Massage

Most often, experts recommend focusing on the cervical-collar zone: the area that most often causes poor blood supply.

5. Avoiding the so-called migraine triggers (causes that lead to an attack).

Eliminate stress, heavy physical exertion. Allow your body to get enough sleep at least 8 hours a day.

Our Mexican pharmacy offers migraine and analgesic medications that you can order with delivery to your address.