Please consult your physician before taking any medication. How does Ovestin Cream work? Main use, Vaginal symptoms of the menopause Ovestin vaginal cream contains the active ingredient estriol, which is a naturally occuring form of the main female sex hormone, oestrogen. Womens’ ovaries gradually produce less and less oestrogen in the period up to the menopause, and oestrogen blood levels decline as a result. The declining levels of oestrogen can cause distressing symptoms, and often affect the delicate lining of the vagina. Oestrogen deficiency can cause vaginal dryness, inflammation or itching, and this in turn can lead to sex being uncomfortable or painful, and to an increased susceptibility to vaginal or urinary infections. Oestrogen can be given as a supplement to replace the falling levels in the body and help reduce the distressing symptoms of the menopause. This is known as hormone replacement therapy (HRT). Oestrogen (in this case in the form of estriol) can also be applied directly to the vagina in the form of vaginal cream, in order to directly supplement the vaginal tissues with oestrogen. This is known as topical HRT and is useful for relieving just the vaginal symptoms of the menopause. Ovestin may also be used for purposes other than those listed in this medication guide.