Please consult your physician before taking any medication. Paxil 20mg 10 Tabs Generic Name: paroxetine (pa ROX a teen) Brand Names: Paxil, Paxil CR, Pexeva What is Paxil CR (paroxetine)? Paroxetine is an antidepressant in a group of drugs called selective serotonin reuptake inhibitors (SSRIs). Paroxetine affects chemicals in the brain that may become unbalanced. Paroxetine is used to treat depression, obsessive-compulsive disorder, anxiety disorders, post-traumatic stress disorder (PTSD), and premenstrual dysphoric disorder (PMDD). Paroxetine may also be used for purposes other than those listed in this medication guide.