Totelle Continuo 1mg/0.125mg 28 tabs Therapeutic signs -Hormone substitution help (HRT) for estrogen deficiency reactions in postmenopausal women more than 1 year postmenopause. -Prevention of osteoporosis in postmenopausal women at high threat of future breaks who are biased of, or contraindicated for, other therapeutic things supported for the balancing activity of osteoporosis. HRT should not be dispatched or continued thwarting cardiovascular disease or dementia. The benefits and dangers of HRT must constantly be deliberately weighed, including thought about the improvement of dangers as help returns. Estrogens with or without progestins should be suggested in any event convincing estimations and for the briefest timeframe dependable with treatment goals and dangers for the individual woman.