Please consult your physician before taking any medication. Brand name: Wellbutrin Generic name: Bupropion hydrochloride Why is Wellbutrin prescribed? Wellbutrin is prescribed to help relieve major depression. Symptoms include a severely depressed mood (for 2 weeks or more) and loss of interest or pleasure in usual activities accompanied by sleep and appetite disturbances, agitation or lack of energy, feelings of guilt or worthlessness, decreased sex drive, inability to concentrate, and sometimes, suicidal thoughts or behavior. Wellbutrin is thought to work by altering levels of the brain chemicals norepinephrine and dopamine. Wellbutrin may also be used for purposes other than those listed in this medication guide.