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Nonexclusive Name: cetirizine (seh TEER ih zeen) Brand Names: Zyrtec What is cetirizine? Cetirizine is an antihistamine. Cetirizine blocks the exercises of the typically event compound histamine in the body. Cetirizine is more unlikely than some distinctive antihistamines to achieve side effects, for instance, lethargy and wooziness. Cetirizine is used to treat the signs of hypersensitivities, for instance, wheezing; runny nose; shivering, tearing, and redness of the eyes; and hives. Cetirizine may in like manner be used for purposes other than those recorded in this medication guide.